Ivan Topisirovic Selected Research

Peptide Initiation Factors (Initiation Factor)

12/2019	Translational reprogramming marks adaptation to asparagine restriction in cancer.
12/2016	Translation Initiation Factors: Reprogramming Protein Synthesis in Cancer.
12/2015	SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex.
4/2015	Targeting the translation machinery in cancer.
12/2012	eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies.
11/2009	p53-dependent translational control of senescence and transformation via 4E-BPs.
3/2009	Stability of eukaryotic translation initiation factor 4E mRNA is regulated by HuR, and this activity is dysregulated in cancer.
12/2004	Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap.
12/2004	Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Ivan Topisirovic Research Topics

Disease

46	Neoplasms (Cancer) 11/2021 - 12/2003
7	Melanoma (Melanoma, Malignant) 01/2022 - 05/2015
7	Carcinogenesis 01/2021 - 11/2009
6	Breast Neoplasms (Breast Cancer) 01/2021 - 01/2018
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022 - 01/2019
2	Prostatic Neoplasms (Prostate Cancer) 01/2021 - 01/2015
2	Hypoxia (Hypoxemia) 01/2020 - 06/2014
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 10/2017 - 12/2004
2	Leukemia 08/2015 - 02/2005
1	Type 2 Diabetes Mellitus (MODY) 01/2021
1	Lung Neoplasms (Lung Cancer) 01/2021
1	Testicular Neoplasms (Testicular Cancer) 10/2020
1	Laminopathies 10/2020
1	Colorectal Neoplasms (Colorectal Cancer) 01/2020
1	Pancreatic Neoplasms (Pancreatic Cancer) 12/2019
1	Lymphoma (Lymphomas) 01/2019
1	Kidney Neoplasms (Kidney Cancer) 12/2018
1	Nervous System Diseases (Neurological Disorders) 01/2018
1	Tuberous Sclerosis (Bourneville's Disease) 01/2018
1	Glioblastoma (Glioblastoma Multiforme) 10/2017
1	Astrocytoma (Pilocytic Astrocytoma) 10/2017
1	Neoplasm Metastasis (Metastasis) 12/2016
1	Carcinoma (Carcinomatosis) 01/2015
1	Virus Diseases (Viral Diseases) 04/2012
1	Leishmaniasis 04/2011
1	Obesity 05/2010
1	Heart Diseases (Heart Disease) 05/2010
1	Renal Cell Carcinoma (Grawitz Tumor) 03/2010

Drug/Important Bio-Agent (IBA)

16	Proteins (Proteins, Gene)FDA Link 01/2021 - 02/2005
12	Eukaryotic Initiation Factor-4EIBA 01/2021 - 12/2003
10	Mechanistic Target of Rapamycin Complex 1IBA 11/2021 - 03/2010
9	Peptide Initiation Factors (Initiation Factor)IBA 12/2019 - 12/2004
5	BiguanidesIBA 12/2018 - 06/2012
4	MTOR InhibitorsIBA 10/2021 - 03/2010
3	Pharmaceutical PreparationsIBA 01/2021 - 12/2015
3	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 01/2015
3	EnzymesIBA 01/2021 - 01/2016
3	Messenger RNA (mRNA)IBA 12/2019 - 03/2009
3	Phosphotransferases (Kinase)IBA 12/2019 - 12/2018
3	Serine (L-Serine)FDA Link 12/2018 - 12/2014
2	fibroblast growth factor 21IBA 01/2022 - 01/2019
2	Adenosine Triphosphate (ATP)IBA 01/2021 - 01/2018
2	AntigensIBA 01/2021 - 10/2020
2	Antineoplastic Agents (Antineoplastics)IBA 01/2021 - 12/2014
2	Hormones (Hormone)IBA 12/2019 - 01/2019
2	Estrogen Receptor alphaIBA 12/2019 - 01/2015
2	AsparagineIBA 12/2019 - 12/2018
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 12/2019 - 11/2017
2	isocitric acid (isocitrate)IBA 10/2017 - 01/2016
2	Tricarboxylic AcidsIBA 10/2017 - 01/2016
2	Oxidoreductases (Dehydrogenase)IBA 10/2017 - 01/2016
2	Eukaryotic Initiation Factor-4F (EIF4F)IBA 12/2015 - 04/2015
2	Metformin (Glucophage)FDA LinkGeneric 12/2014 - 06/2012
1	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 01/2022
1	arginyltransferaseIBA 01/2022
1	Hypoglycemic Agents (Hypoglycemics)IBA 01/2021
1	Phenformin (Fenformin)IBA 01/2021
1	Recombinant ProteinsIBA 01/2021
1	Sodium-Glucose Transporter 2 InhibitorsIBA 01/2021
1	Glycogen Synthase Kinase 3IBA 01/2021
1	CanagliflozinIBA 01/2021
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2021
1	Sodium-Glucose Transport ProteinsIBA 01/2021
1	Dual Specificity Phosphatase 6IBA 01/2021
1	beta-lapachoneIBA 01/2021
1	Paclitaxel (Taxol)FDA LinkGeneric 10/2020
1	Lamin Type A (Lamin A)IBA 10/2020
1	Immunoglobulins (Immunoglobulin)IBA 10/2020
1	CopperIBA 01/2020
1	RNA IsoformsIBA 01/2020
1	5' Untranslated Regions (5' UTR)IBA 01/2020
1	Protein Isoforms (Isoforms)IBA 01/2020
1	ProteomeIBA 12/2019
1	Activating Transcription Factor 4IBA 12/2019
1	Aspartate-Ammonia Ligase (Asparagine Synthetase)IBA 12/2019
1	Amino Acids FDA Link 12/2019
1	TOR Serine-Threonine KinasesIBA 12/2019
1	Lysine (L-Lysine)FDA Link 01/2019
1	Peptide Elongation Factors (Elongation Factor)IBA 01/2019
1	CSK Tyrosine-Protein KinaseIBA 01/2019
1	Histone MethyltransferasesIBA 01/2019
1	Aspartic Acid (Aspartate)FDA Link 12/2018
1	Glutamine (L-Glutamine)FDA Link 12/2018
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018
1	AntioxidantsIBA 01/2018
1	Proto-Oncogene Proteins c-kit (Proto-Oncogene Protein c-kit)IBA 11/2017
1	SBI-0640756IBA 12/2015
1	Arginine (L-Arginine)FDA Link 08/2015
1	VemurafenibIBA 05/2015
1	Estrogen ReceptorsIBA 01/2015
1	Estrogens (Estrogen)FDA Link 01/2015
1	AndrogensIBA 01/2015
1	RibonucleoproteinsIBA 06/2014
1	Telomerase (Telomerase Reverse Transcriptase)IBA 06/2014
1	torinIBA 06/2014
1	Biomarkers (Surrogate Marker)IBA 12/2012
1	Mitogen-Activated Protein KinasesIBA 11/2012
1	Phosphatidylinositols (Phosphatidylinositol)IBA 11/2012

Therapy/Procedure

6	Therapeutics 01/2021 - 03/2010
1	Immunotherapy 01/2021